Preheat your oven to 350°F (175°C).
Cook the macaroni according to package instructions until al dente.
In a large saucepan, melt the butter over medium heat.
Whisk in the flour and cook for about 1 minute.
Gradually pour in the milk, whisking continually.
Cook the mixture until it thickens and bubbles.
Stir in the cheeses, Dijon mustard, garlic powder, and onion powder until melted and smooth.
Season with salt and pepper to taste.
Combine the cooked macaroni with the cheese sauce, ensuring all noodles are well-coated.
Transfer the mixture into a greased baking dish and smooth the top.
In a small bowl, mix the breadcrumbs with the melted butter and spread over the top.
Bake in the preheated oven for 25-30 minutes or until golden and bubbly.
Let cool for a few minutes before serving.